"The chemist who designs and completes an original and esthetically pleasing multistep synthesis is like the composer, artist or poet who, with great individuality, fashions new forms of beauty from the interplay of mind and spirit."---------E. J. Corey, Nobel Laureate
Our research interests lie primarily in various aspects of synthetic organic chemistry with a strong focus on the stereoselective synthesis of privileged structure-based small organic molecules. Synthesis of chiral heterocycle-based small molecules is one of the most active areas of current research in organic chemistry. It is a well-known fact that more than half of all known organic compounds are heterocyclic compounds. Also, they are found as key structural units in more than 90% of the new marketed drugs. We are interested in the design, synthesis and biological evaluation of 'small but smart' libraries of chiral heterocycle-based small molecules. In particular, we are involved in the synthesis of chiral indoline, 1,2,3,4-tetrahydroisoquinoline-, 2,3-dihydrobenzofuran, and chroman-based natural product-like molecules. Our methodological interests lie primarily in the areas of Lewis/Brønsted acid-catalysed intramolecular ring opening of strained small ring structures for the preparation of new classes of functionalized heterocycles. Due to their inherent ring strains, these cyclic compounds serve as versatile platforms for the synthesis of natural products and large number of synthetic compounds for drug discovery research. We are developing methods which involve domino reactions initiated by ring-opening of strained small rings to access diverse chiral benzo-fused heterocycles. Our group has reported a number of epoxide/aziridine ring-opening cyclization for the construction of diverse benzofused heterocycles.
Our research interests lie primarily in various aspects of synthetic organic chemistry with a strong focus on the stereoselective synthesis of privileged structure-based small organic molecules. Synthesis of chiral heterocycle-based small molecules is one of the most active areas of current research in organic chemistry. It is a well-known fact that more than half of all known organic compounds are heterocyclic compounds. Also, they are found as key structural units in more than 90% of the new marketed drugs. We are interested in the design, synthesis and biological evaluation of 'small but smart' libraries of chiral heterocycle-based small molecules. In particular, we are involved in the synthesis of chiral indoline, 1,2,3,4-tetrahydroisoquinoline-, 2,3-dihydrobenzofuran, and chroman-based natural product-like molecules. Our methodological interests lie primarily in the areas of Lewis/Brønsted acid-catalysed intramolecular ring opening of strained small ring structures for the preparation of new classes of functionalized heterocycles. Due to their inherent ring strains, these cyclic compounds serve as versatile platforms for the synthesis of natural products and large number of synthetic compounds for drug discovery research. We are developing methods which involve domino reactions initiated by ring-opening of strained small rings to access diverse chiral benzo-fused heterocycles. Our group has reported a number of epoxide/aziridine ring-opening cyclization for the construction of diverse benzofused heterocycles.